by Mark Curtis, ABC 6 Chief Political Reporter
This debate could be a real slugfest between Vice President Joe Biden, and his Republican challenger Paul Ryan.
The reason being, by most accounts Mitt Romney handily defeated President Obama in their first debate.
Rhode Island College Communications Professor Valerie Endress said, "Ryan will have to continue the momentum to make it real. On the other hand, Obama needs a comeback and it needs to start with Joe Biden."
One big challenge is not to make a big mistake.
That's because the news coverage and analysis of the debate goes on for days.
"It becomes the topic of discussion for the next six days. And, in an election of this type, where news needs to cover something ongoing, it puts more pressure on what's happening in the debate," said Rhode Island College Communications Professor Kay Israel.
ABC 6 Political Reporter Mark Curtis said, "Big question is, do these VP debates matter anyway? Remember the biggest gaffe of all-time was when Republican Dan Quayle compared himself to John F. Kennedy. We'll the Republicans won that race anyway.
A Gallup study of previous Vice Presidential debates showed that none of them was factor in the outcome of the election.
But this time there is a late breaking controversy over turmoil in the Mideast:
"This Libya situation could become very, very important because it's that bump in the road, as the president said. It could be a bump in the campaign for Mr. Obama," said ABC 6 Chief Political Analyst Buddy Cianci.
A recent poll shows that President Obama is leading the race, by just one percentage point.