TORONTO (AP) -- John Lackey left with a strained biceps in his first start since September 2011, grabbing his right arm in pain and coming out in the fifth inning Saturday as the Boston Red Sox lost to the Toronto Blue Jays 5-0.
Lackey (0-1) missed last season following elbow ligament-replacement surgery in November 2011. He allowed a two-run homer to J.P. Arencibia in the fourth, and then clutched his arm and jumped around the mound in pain after throwing low and inside to Jose Reyes on a 2-2 pitch with one out in the fifth
Teammates and manager John Farrell came to the mound before Lackey walked off with Red Sox trainer Rick Jameyson and was replaced by Alfredo Aceves, who threw ball four.
There was no immediate word on the severity of Lackey's injury, or how much time he might miss.
Lackey signed an $82.5 million, five-year contract with Boston in December 2009 after eight seasons with the Angels. He allowed two runs and five hits in 4 1-3 innings with eight strikeouts and one walk, throwing 50 of 76 pitches for strikes and reaching 94 mph.
Colby Rasmus hit a three-run homer in the sixth off Aceves, a drive off the facing of the third deck in right center,
J.A. Happ (1-0) combined on a two-hitter with Steve Delabar, Aaron Loup and Sergio Santos.
After Jacoby Ellsbury's leadoff double in the first, the Red Sox didn't get another hit until Dustin Pedroia reached on an infield single with two outs in the ninth. Mike Napoli followed with a drive to deep center, but Rasmus made a fine running catch before crashing into the wall.
Pedro Ciriaco drew a one-out walk in the second, advanced on a wild pitch and took third on a throwing error by the catcher Arencibia, then was thrown out at the plate by first baseman Edwin Encarnacion while trying to score on Ellsbury's grounder.
Happ struck out six and walked three in 5 1-3 innings.
Toronto was without slugger Jose Bautista for the second straight day because of a sore right ankle. The two-time major league home run leader was hurt stepping on first base while beating out a double play Thursday. Bautista hit in the cage and ran on the field before the game.
Lind walked to begin the sixth and stole second, just the sixth stolen base of his career. Mark DeRosa drew a one-out walk before Rasmus clobbered a three-run shot off the facing of the third deck in right center, his second.
NOTES: Attendance was 45,797. ... Toronto selected the contract of RHP Dave Bush from Triple-A Buffalo and designated RHP Jeremy Jeffress for assignment. Jeffress made his first appearance of the season in Friday's loss to Boston, giving up a solo homer to his first batter, Will Middlebrooks. ... Red Sox SS Jose Iglesias, who left Friday's game two innings after being hit on an arm by a pitch, was held out of the starting lineup. Manager John Farrell said it was a scheduled day off. ... Bench coach Torey Lovullo, not Farrell, brought the lineup card to home plate before the game.